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Invisible Forces

The world is changing at a rapid pace. And many of the forces driving these changes can't be seen at all. Jefferies' Invisible Forces podcast series covers the future of different corners of the global economy and the opportunities that lie ahead.

Hosted by

Shannon Murphy

Erin Shea

Jefferies insiders Shannon Murphy and Erin Shea host Invisible Forces, a show about the unseen influences that are rapidly transforming our way of life and global economy. With surprising stories and expert interviews, we're looking into the future at where we'll be living, how we'll be working, what we'll be buying...and why.

Invisible Forces Season 3

S3:EP5

It's Not Where, it's What: Targeted Oncology and the Keys to Solving Cancer

Rather than treating cancer based on its location in the body, scientists have found another, more effective, more targeted way to treat cancer — one that you need a code to unlock. On this episode we look at the surprising history and the hopeful future of immunotherapy, and how the genetic code of cancer itself is being used. We speak with Jefferies’ Mike Yee, Johns Hopkins’ Neeha Zaidi, and Neville Sanjana from the NY Genome Center.

March 28, 2022 | 20:39

S3:EP4

When Your Home is the Hospital: Tech-Enabled Healing

One of the fastest-growing areas of healthcare is focusing less on what’s wrong with you, but where the healing actually happens. In this episode we learn about innovation beyond the drugs – how doctors are providing medical care right to a patient’s front door. We speak with Jefferies’ Brian Tanquilut, Medically Home’s Raphael Rakowski, and Professor and author Elizabeth Krupinski of Emory University.

March 14, 2022 | 19:44

S3:EP3

Cracking the Code that Runs Us: The Future of Gene Therapy

The discovery of DNA in the 1850’s allowed us to see into the genetic code of individual humans. Fast forward to the 21^st century, scientists are developing a technique to rewrite those genes. In this episode, we look at the ways gene editing is being used to turn that century-old breakthrough into the future of medicine. We speak with Jefferies’ Will Sevush, Beam Therapeutics’ Pino Ciarmella, Neville Sanjana from the NY Genome Center, and Dr. Paul Offit at the Children’s Hospital of Philadelphia.

February 28, 2022 | 19:39

S3:EP2

Breaking the Blood Brain Barrier: The Quest to Cure Neurodegeneration

Neurological degenerative illnesses like Alzheimer’s, Parkinson’s and ALS have proven difficult to treat because of one of the strongest security systems in the human body: The Blood Brain Barrier. This episode looks at how modern medicine might be able to finally break down that barrier for good. We speak with Jefferies’ Mike Yee, Denali Therapeutics’ Ryan Watts, and Dr. Rachita Sumbria of Chapman University.

February 14, 2022 | 18:25

S3:EP1

From Zero to Hero: The Story Behind the mRNA Vaccine

This new season kicks off with a medical breakthrough story you might THINK you know, but isn't so straightforward. The "speedy" development of mRNA technology, behind many Covid-19 vaccines, actually took decades of twists and turns. We speak with Jefferies’ Mike Yee, Acuitas Therapeutics’ Thomas Madden, and Joe Miller of the Financial Times.

January 31, 2022 | 18:40

S3:EP0

Bonus Episode: Hopeless Optimism

Throughout this season, we highlight medical breakthroughs stemming from investment: of time, of money, of research and ingenuity. Exploring the common thread that links all these incredible stories together: the alchemy that brings about these life-saving innovations in healthcare. We speak with Jefferies’ Mike Yee and Will Sevush, Johns Hopkins’ Neeha Zaidi, and Dr. Rachita Sumbria of Chapman University.

January 31, 2022 | 19:23

S3:EP Trailer

Season 3 Trailer: What Healthcare Breakthrough Are You Waiting For?

Invisible Forces is a podcast that investigates the unseen influences that drive our spending, our saving and our global economy. Hosted by Jefferies' insider Shannon Murphy, season three is all about one invisible force – the alchemy that can turn a series of unlikely events, surprises and setbacks into medicine’s biggest successes. We’ll hear from biotech industry leaders and our own Jefferies experts about some of the biggest breakthroughs in medical history – and the investments that brought them into reality.

January 28, 2022 | 1:31

Invisible Forces Season 2

S2:EP6

An All-Encompassing Economy

Nadia Batchelor, the Co-Founder & Co-Head of J-NOBLE – Jefferies Network of Black and Latinx employees, Kristina Liburd (Founder & CEO of Viageur) and Boyuan Gao (Founder & Principle of Project Inkblot), Stephanie Wemusa (VP Diversity & Inclusion at TalVista) and Evie Cheung (Designer at Doblin), explore how the powerful social justice movement in 2020 created lasting changes for businesses and consumers around the world.

October 06, 2020 | 25:30

S2:EP5

A New Peace of Mind

Jefferies experts Dominic Lester and Ramin Safai, are joined by Christian Cerda, the CEO of Simplisafe and Thomas Smyth, founder and CEO of Trim. In this episode, we explore how this need for fortification has been accelerated by work-from-home orders and lockdowns, and how this year has changed our idea of security for good.

September 22, 2020 | 24:03

S2:EP4

Lean, Mean and Green: The Future of Sustainable Businesses

Simon Powell, Jon Matuszewski, and Dominic Lester are joined by Tom Quinn, the President of Halio North America, Erin Wallace, the VP of Integrated Marketing at Thred Up and Thrive Market CEO Nick Green, to dig into how tech is powering green innovations in a wide range of industries. We hear from business leaders how this force is not only good for the Earth, but good for your company's bottom line.

August 25, 2020 | 22:59

S2:EP3

The Changing Face of Urban Space

Jon Matuszewski, Storm Duncan and Nadia Batchelor join from Jefferies to discuss whether the city-dwellers considering swapping skylines for suburbs will really move, and what implications this may have on the future of city space? Taco Carlier, the co-founder of the Dutch e-bike company Van Moof explores what the pandemic might do for the future of urban transportation.

August 25, 2020 | 24:05

S2:EP2

When Tech is Your Tailor

Jefferies experts Cameron Lester and Jared Holz explore how the shift towards hyper-personalized goods and services is revolutionizing the retail and healthcare landscapes. They are joined by Nick Green, the co-founder and CEO of Thrive Market, Chris Merkle, the co-founder of MIME, and Dr. William Li, a physician and bestselling author of Eat to Beat Disease.

August 11, 2020 | 26:35

S2:EP1

Crying Over Spilled Milk: The Disruption Solution

In the season two premiere of Invisible Forces, Jefferies’ Aneta Markowska and Storm Duncan are joined by business leaders and historians to look at how the pandemic is rapidly transforming everything along the $10 trillion global supply chain - from vital medical equipment to fresh produce to jigsaw puzzles and beyond.

July 28, 2020 | 28:56

Invisible Forces Season 1

S1:EP6

What Makes Makers Tick?

In our season 1 finale, we explore the force that has underpinned every episode in the season: the brilliant entrepreneurs, thinkers, and founders behind groundbreaking and culture-shifting companies. We talk to three successful founders about the entrepreneurial spirit that drives their work: Aaron Rasmussen, who just launched Outlier.org and co-founded MasterClass, Angela Lee of 37 Angels, and Transfix CEO, Drew McElroy.

October 15, 2019 | 34:22

S1:EP5

Building a Boom: Brand Lessons for Creating Explosive Value

Jefferies expert Steph Wissink walks us through what’s been happening in the beauty industry over the past decade. It’s a sector that just underwent a long boom period. Conor Begley, co-founder of Tribe Dynamics, shares why “Earned Media Value” is one of the most powerful metrics for companies in search of their “next big thing.”

October 08, 2019 | 19:59

S1:EP4

A Tech Revolution for Financial Services

Our hosts are joined by Jefferies’ Vaughn Harvey, and Jesse McWaters, financial innovation lead for the World Economic Forum, to discuss artificial intelligence in the financial services sector. We’ll also hear from Betterment CEO Jon Stein and IEX CEO Brad Katsuyama, two entrepreneurs already relying on AI to disrupt different areas of the financial space – from online financial advising to building better exchanges for the next decade.

October 01, 2019 | 28:56

S1:EP3

You Are What You Buy

Listen to views on consumers’ interest in authenticity from Jefferies expert, Randy Konik, along with the Head of Diamond Producers’ Association, and an expert from Wharton Business School.

September 24, 2019 | 34:22

S1:EP2

Biotech - From Bench to Bedside

Curious about the cutting edge of biotech? Jefferies’ Michael Yee and Jared Holz walk through some of the biggest biotech breakthroughs of the last decade, and speak with a family who expects an entirely different life for their son because of it.

September 17, 2019 | 19:25

S1:EP1

The $10 Trillion Question

In the premiere episode of Invisible Forces, Jefferies’ Storm Duncan joins our hosts to weigh in on how technology can continue to help improve mobility and efficiency. We’ll also hear from two entrepreneurs disrupting different areas of mobility: Lime CEO, Brad Bao, and Drew McElroy, the CEO of Transfix.

September 10, 2019 | 19:25

S1:EP0

Introducing: Invisible Forces

Jefferies’ first podcast series exploring the surprising currents moving markets, driving innovation and disrupting entire business models

September 05, 2019 | 28:56